Ozone Therapy in Diabetes Mellitus
Diabetes Mellitus is a complex and chronic condition marked by a disruption in carbohydrate metabolism, leading to hyperglycemia resulting from insufficient insulin production or utilization. This disorder involves a diminished responsiveness of insulin-sensitive tissues to insulin, causing endothelial cell damage due to elevated glucose concentrations. The significant social and economic consequences of diabetes and its complications make it a major health concern, profoundly impacting the quality of life for affected individuals.
Diabetic patients face a heightened risk of lower extremity amputations, with the incidence being 15 to 40 times higher than in non-diabetic individuals. Additionally, the prevalence of cardiac diseases and strokes is 2 to 4 times greater in diabetic patients. The life expectancy of individuals with diabetes is 10 to 15 years less compared to their non-diabetic counterparts. Moreover, diabetic patients experience a higher frequency of hospitalizations, increased health expenses, and larger budgets allocated for the treatment of complications, further emphasizing the substantial burden associated with diabetes.
Ozone therapy protocol
Ozone Therapy Protocol
The Ozone therapy protocol involves systemic treatments such as Rectal Insufflation, Major Autohemotherapy, or Ozonized Saline. These methods aim to enhance circulation and yield anti-inflammatory results.
Mechanism of Action of Ozone Therapy:
- Stimulation of Anti-oxidative Enzymes: Ozone induces oxidative stress in cells, activating their natural defense mechanisms, particularly anti-oxidative enzymes.
- Energy Support for Anti-oxidative Enzymes: To bolster anti-oxidative enzymes, cells require energy, prompting increased glucose uptake from the blood. Cells convert glucose into energy, supporting anti-oxidative enzymes and reducing blood glucose levels independently of insulin.
- Improved Circulation and Oxygenation: Utilizing glucose for energy production generates 2,3 DPG, facilitating the release of more oxygen from hemoglobin. The increased energy is utilized to maintain cell membrane integrity, preserving the biconcave shape of red blood cells and enabling smooth passage through small capillaries.
- Action on Vessel Wall Cells and Nitric Oxide Production: Ozone acts on vessel wall cells, promoting the production of Nitric Oxide (NO), a potent vasodilator. NO induces vessel dilation, enhancing circulation by opening up blood vessels.
- Induction of White Blood Cells and Immune Enhancement: Ozone stimulates white blood cells, contributing to improved immunity.
- Stimulation of Platelets and Blood Thinning: Ozone stimulates platelets and facilitates blood thinning, promoting better blood flow and circulation.