Osteoarthiritis

Causes Of Osteoarthritis:

Mechanical Forces Leading To Wear And Tear Along With Mediators Of Pain In Chronic Inflammatory Reaction.

. Edema And Infammation Leading To Ischemia

Collagenase And Proteoglycanases Secreted By Activated Chondrocytes And Monocytes Leading To Matrix Degeneration, Softening And Destruction Of Knee Joint.

Mode Of Administration :

Ozone Therapy Is Given In The Form Of Injections Under Aseptic Precautions Around The Knee (Peri Articular Injections For About 10 To 15 Sittings) And Inside The Knee Joint (Intra Articular For About 3 To 5 Sittings)

Mechanism Of Action Of Ozone :
. Proteolytic Enzymes And

Endogenous ROS Are Inhibited. . Bradykinin And Infammatory PG

Release Is Inhibited.

. Release Of Immunosuppressive Cytokines TGF-Beta And IL-10 May Inhibit Inframmation.

Disappearance Of Edema Leads To Improved Circulation, Washing Away Of Lactic Acid And Relief In Pain. . Ozone Injections Act As An Analgesic.

. Algic Stimulation Of Skin Can Reduce Pain Through Mechanism Of Diffuse Noxious Inhibitory Control.

Many Other Systemic As Well As Local Diseases Can Be Effectively Treated With Ozone Therapy. OZONE THERAPY Can Be Considered Supportive Therapy