Ozone Therapy for Non-Healing Ulcers: Indications
- Diabetic ulcers
- Ulcers due to arterial insufficiency
- Venous ulcers
- Non-healing wounds
- Burns
- Accidental wounds
- Intractable fistulas and wounds resulting from surgical operations, such as infected mesh following inguinal hernia operations, fistulas after acute appendicitis with diffuse peritonitis, anal fistulas following incision and drainage for perianal abscesses, etc.
Ozone can be applied externally through various methods, including:
- Bagging the affected wound
- Cupping the affected wound
- Ozonated water soaks
- Ozonated oil applications, such as Rapid Heal oil
Mechanism of Action of Ozone in the Treatment of Non-Healing Ulcers:
- Improves Blood Circulation and Tissue Oxygenation:
- Increases oxygen release at the tissue level by elevating 2,3 DPG.
- Induces vasodilation by generating Nitric Oxide.
- Raises ATP levels, influencing membrane potential and enhancing the deformability and elasticity of red blood cells (RBCs).
- Stimulates Immune System and Pathogen Elimination:
- Modulates cell-mediated immunity, controlling cytokines like IL, IL2, IL-12, INFY, and TNFO.
- Regulates humoral immunity through IL4, IL5, IL-10, and TGFB.
- Affects leucocytes, particularly Helper T Lymphocytes, by modifying cytokine synthesis, influencing pro-inflammatory/anti-inflammatory cytokines like IL-6, IL-4, TNFO, IFN-B, IFNY, IL-2, and IL-10.
- Platelets Activation and Growth Factor Release:
- Stimulates platelets to produce PDGF (Platelet-Derived Growth Factor), promoting fibroblast proliferation and extracellular matrix production.
- Releases chemotactic factors like TGFB (Tumor Growth Factor B) and IL8 (Interleukin 8), fostering collagen deposition, matrix formation, and angiogenesis.
- Germicidal Ozone Properties:
- Exhibits potent bactericidal, fungicidal, and virucidal properties, commonly employed for disinfecting infected wounds.
- Alters bacterial cell membrane structure by attacking PUFA, leading to increased porosity, cell damage, rupture, and death.
- Activates macrophages and T cells, promoting phagocytosis and antibody production to effectively combat bacteria.
- Blocks viral replication through the ozone-induced synthesis of IFN (Interferon).
- Displays efficacy against fungi, particularly in higher concentrations.
- Enhances and Activates Body’s Own Antioxidants:
- Despite its oxidant nature, ozone stimulates the body’s antioxidant enzymes such as glutathione, peroxidase, catalase, and superoxide dismutase.
- Prepares the body for subsequent oxidative stress by enhancing its antioxidant defenses.